Sweating HOME
Sweating .ca
Your Guide to Excess Sweating/Hyperhidrosis Treatment Information.
Skin Care Guide Canada
Excess Sweating/Hyperhidrosis About Us Dermatology Glossary Skin Care Network Sweating .CA Site Map



Neuromuscular Blocking Agents

These agents block acetylcholine and inhibit the transmission of nerve impulses that trigger sweating. Botulinum toxin (Botox®) is injected under the skin and produces a sustained, localized decrease in sweating. It may be used to treat underarm, palm and sole hyperhidrosis.

Each injection produces an area of dryness approximately 1.2 cm in diameter for a number of months.

Underarm treatments are well tolerated but injections to the thicker skin of the palm and soles of the feet may be painful and may require a regional nerve block to produce local anesthesia.

Here are some quick facts on Botox® injections;

  • FDA indicated and HPB approved in Canada for axillary hyperhidrosis
  • Blocks acetylcholine release from nerve endings, thus sweat gland not stimulated
  • Highly effective (more than 90%)
  • Effect is transient (7.8 month average, 40% more than a year)
  • Effective for axillae, palms, plantar, face and other localized areas
  • Side effects rare for axillae other than local mild discomfort during injection and rare flu like symptoms
  • For hands: nerve blocks with rare median nerve injury risk, intrinsic hand muscle weakness in some people (transient)
  • Facial muscle paralysis can be a result of facial hyperhidrosis treatment with Botox®
  • Costly - Drug alone: C$400 for axillae, $800 for palms and $1600 for plantar surface per treatment